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KMID : 0614619940260040655
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Korean Journal of Gastroenterology
1994 Volume.26 No. 4 p.655 ~ p.661
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Clinical Significance of Serum and Ascites 7S Collagen in the Patients with Various Liver Diseases
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한경학
박성민/조해석/전우규/이만호/정을순/이상종
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Abstract
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The 7S collagen is a large collageneous fragment of basement membrane, which was recently reported to have increased activity in various liver diseases. In order to determine whether 7S collagen concentrations of serum and ascites is helpful to
make
diagnosis of various liver diseases, we measured 7S collagen concentrations of serum and ascites in various liver diseases. Noraml values obtained from 20 healthy controls were 3.12±0.70ng/ml for 7S collagen concentration in the serum
concentrations of
the 7S collagen exceeding 4.52ng/ml (Mean+2SD) was defined as positive. The mean values of 7S collagen concentration of serum were 5.65±3.20ng/ml in chronic hepatitis, 5.21±4.67ng/ml in acute hepatitis, 12.54±5.45ng/ml in liver cirrhosis, and
10.05±4.72ng/ml in hepatoma. The positive rate was extremely high in hepatoma(100%) and liver cirrhosis(97.1%) but low in chronic hepatitis(59.9%) and acute hepatitis(33.3%). The mean values of 7S collagen concentration in ascites were
59.05±18.20ng/ml in liver cirrhosis and 55.32±4.23ng/ml hepatoma. The 7S collagen concentration of ascites shows no paraller correlation to that of serum in patients with ascites.(Korean J Gastroenterol 194 ; 26 : 655-661)
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